ACUTE MYELOID LEUKEMIA AML


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setegn eshetie    on Aug 21, 2009 Says :

knowing about the types of leukemia is essential
setegn eshetie    on Aug 21, 2009 Says :

i am very happy to recieve information concerning leukemia
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1 : ACUTE MYELOID LEUKEMIA (AML) Presented by Judi McCarter
2 : Clinical Overview Acute myeloid leukemia (AML) is one of four types of leukemia. AML is cancer of the blood-forming tissue (bone marrow). Normal bone marrow produces red cells, white cells, and platelets. AML causes bone marrow to produce too many immature white blood cells (blast cells). Suppresses normal blood cell production. Anemia, leucopenia, thrombocytopenia
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5 : Clinical Overview AML is acquired from genetic damage to the DNA of a single cell in the bone marrow; resulting in malignancy. Diagnosed by clinical laboratory tests performed on blood and bone marrow. Primarily affects adults and children younger than one year old. Incidence is 2.5 out of 100,000 people.
6 : Signs and Symptoms Fatigue Shortness of breath on exertion Easy bruising Petechiae Bleeding in the nose or from the gums Prolonged bleeding from minor cuts Recurrent minor infections or poor healing of minor cuts Loss of appetite or weight loss Mild fever
7 : 11,920 new cases expected in U.S. in 2004 8,870 estimated deaths – 2004 M:54%, F:46% Statistics 5-year survival rate in adults under 65 is 33% 5-year survival rate in adults over 65 is 4% Incidence: Mortality: Prognosis: Prognosis: Prognosis: 20-30% experience remission or are cured Sources: American Cancer Society, 2003; The Leukemia & Lymphoma Society, 2003
8 : Risk Factors Age Older adults are more likely to develop AML Smoking 20% of AML cases are linked to smoking Doubles the risk of disease in people older than 60 Genetic disorders Down syndrome, Fanconi’s anemia High doses of radiation Long-term survivors of atomic bombs Previous chemotherapy treatment Breast cancer, ovarian cancer, lymphoma Exposure to industrial chemicals Benzene
9 : Treatments for AML Chemotherapy Phase One – Remission induction therapy Phase Two – Remission continuation therapy Radiation therapy for certain cases Bone marrow transplantation
10 : Prognosis for AML Survival rates greatly improved over past 25 years. Majority of patients still succumb to the disease. Remission rates inversely related to age. 5-year survival rate in adults under 65 is 33% 5-Year survival rate in adults over 65 is 4% Dependent upon several factors. Age White blood cell count Presence of translocations in bone marrow
11 : The Future Clinical trials New drug treatments Vaccines Immunotherapy Leukemia type-specific therapy Gene therapy Block encoding instructions of an oncogene Target the oncoprotein Blood and marrow stem cell transplantation Bone marrow transplantation provides long-term, disease-free survival among patients in

 

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