Asthma Pathophysiology


×
Rating : Rate It:
 
 
kimathi philemon mwongera    on May 13, 2013 Says :

great presentation
manoj dias    on Feb 07, 2013 Says :

good presentation.
charan vallabhu    on Jul 06, 2012 Says :

superb presentation
arsh    on Jan 24, 2012 Says :

thnx........
li    on Feb 25, 2011 Says :

good
doc    on Dec 07, 2009 Says :

too goog
Post a comment
    Post Comment on Twitter
Comments:  
17 Favorites
aroooj1992,   favourited this   1 Years ago.
zam-immuno,   favourited this   2 Years ago.
rashidahyasin09,   favourited this   2 Years ago.
rhoda3Zx,   favourited this   2 Years ago.
zahra2266,   favourited this   2 Years ago.
nikhithatom,   favourited this   2 Years ago.
monu yadav,   favourited this   2 Years ago.
sallyp,   favourited this   3 Years ago.
sacredheart,   favourited this   3 Years ago.
First Prev [1] 2 Next Last



  Notes
 
 
1 : ?!*$# “Twenty years from nowyou will be more disappointedby the things you didn't do than by those you did.” ...Catch the trade winds in your sails, explore, dream, discover & live….! ”                         - Mark Twain
2 : Jun-09 Asthma Pathophysiology Dr. Venkatesh M. Shashidhar. Senior Lecturer in Pathology Fiji School of Medicine
3 : Jun-09 Asthma: Chronic Inflammatory disorder of bronchi characterized by Episodic, reversible bronchospasm resulting from an exaggerated bronchoconstrictor response to various stimuli (allergy) Affects 10% of children & 5%-7% adults Highest in NZ, Low in Fiji ~ 1% ?
4 : Jun-09 Asthma Facts ? Asthma is “all in the mind.” You will “grow out of it.” Asthma can be cured, Not very serious disease and nobody dies from it. You are likely to develop asthma if someone in your family has it. You can “catch” asthma from someone else who has it. Moving to a different location can cure asthma. People with asthma should not exercise. Asthma does not require medical treatment. Medications used to treat asthma are habit-forming. Someone with asthma can provoke episodes anytime. Asthma can spread to other persons through caughing. Asthma is born with you. Familial/genetic.
5 : Jun-09 Percent Change in Age-Adjusted Death Rates, U.S., 1965-1998 0 0.5 1.0 1.5 2.0 2.5 3.0 Proportion of 1965 Rate 1965 - 1998 1965 - 1998 1965 - 1998 1965 - 1998 1965 - 1998 –59% –64% –35% +163% –7% Coronary Heart Disease Stroke Other CVD COPD All Other Causes
6 : Jun-09 INFLAMMATION Pathogenesis:
7 : Jun-09 Asthma Pathogenetic Types: Extrinsic (Allergic/Immune) Atopic - IgE Occupational - IgG A. Bronchopulomonary Aspergillosis - IgE Intrinsic (Non immune) Aspirin induced Infections induced
8 : Jun-09 Pathogenesis - Atopic Asthma:
9 : Jun-09 Mast cells in Asthma Pathogenesis:
10 : Jun-09 Eosinophils in Asthma Pathogenesis:
11 : Jun-09 Lung Morphology in Asthma Bronchial inflammation Edema, Mucousplugging Bronchospasm Obstruction Over inflation/Atelectasis COPD
12 : Jun-09 Lung Hyperinflation in Asthma
13 : Jun-09 Thick bronchi with Mucous plugs
14 : Jun-09 Mucous plug in asthma:
15 : Jun-09 Asthma - Micropathology Patchy necrosis of epithelium Sub-mucosal glandular hyperplasia Hypertrophy of bronchial smooth muscle Eosinophils, mast cells; lympho (TH2, CD4) Mucous plugs, Curschmann spirals, Charcot Layden crystals.
16 : Jun-09 Asthma Microscopic Pathology Obstructed Inflammed Bronchi
17 : Jun-09 Asthma - Bronchial morphology inflammation Eosinophils Gland hyperplasia Mucous plug in lumen Hypertrophy of muscle layer
18 : Jun-09 Asthma - Bronchial morphology Inflammation Mucous Plug Eosinophils
19 : Jun-09 Asthma – TH2 lymphocytesimmunostaining)
20 : Jun-09 Eosinophils in Asthma:
21 : Jun-09 Curschmann's spirals:
22 : Jun-09 New Pathology & Drugs in Asthma: Leukotriences - significant role in Asthma Mast cells and Eosinophil - Cytokines. Arachidonic acid - Lipo-oxygenase – LTD4 Bronchospasm – Cys-LT1 receptor Zileuton – Lipoxygenase inhibitor Montelukast & zafirlukast - inhibit CysLT1
23 : Jun-09 5-LO inhibitors Antileukotrienes
24 : Jun-09 History of Leukotrienes: Samuelsson et al. (1979) Stockholm found arachidonic acid metabolites in anaphylaxis, (SRS) called them "leukotrienes.“ now known to be cysteinyl leukotrienes (LT-C4, D4 and E4). * Samuelsson later won the Nobel Prize
25 : Jun-09 The Reality ? Asthma is not yet curable * Underdiagnosis & Undermanagement Therapy is still evolving Hope ? Better understanding of Pathology New line of Promissing Drugs. Proper management ? normal life.
26 : Jun-09 Thank You… Dr. Venkatesh M. Shashidhar. Senior Lecturer in Pathology Fiji School of Medicine
27 : Jun-09 Asthma Pathology - Modern view Barnes PJ Leukotrienes C4, D4 & E4
28 : Jun-09 Mast cell Degranulation Barnes PJ Normal 5 Seconds 60 Seconds
29 : Jun-09 Mast cell Degranulation Barnes PJ
30 : Jun-09 Type I Hypersensitivity: Barnes PJ

 

Add as Friend By :
Added On : 6 Years ago.
You are likely to develop asthma if someone in your family has it. .... Asthma is a complex disease    more
Views 23144 | Favourite 18 | Total Upload :628022

Embed Code:

Flag as inappropriate


Related  Most Viewed



Free Powerpoint Templates



 



Free Medical PowerPoint Templates | Powerpoint Templates | Tags | Contact | About Us | Privacy | FAQ | Blog

© Slideworld