Basics of Diagnostic Hepatopathology

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Slide 1 : Basics of Diagnostic Hepatopathology Keith J. Kaplan, MD Mayo Clinic
Slide 2 : www.tissuepathology.com
Slide 3 : www.tissuepathology.com “For the King of Babylon stood at the parting of the way at the head of the two ways, to use divination: He made his arrows bright, he consulted with images, he looked in the liver.” Ezekial 21:21
Slide 4 : www.tissuepathology.com Biopsy Experience 10 – 15% of liver biopsies have no specific diagnosis. 30-40% of liver biopsies performed done for evaluation of Hepatitis C. 25% Neoplasms 15% Fibrosis/Cirrhosis 5% each for SH, granulomas, iron overload
Slide 5 : www.tissuepathology.com Indications Mass lesions Abnormal lab tests Decompensating liver disease Staging & prognosis Anti-inflammatory & anti-viral rx Anti-fibrotic & cholestatic rx Transplantation
Slide 6 : www.tissuepathology.com Goals for the Pathologist Confirm diagnosis Ascertain etiology Grade activity – “Grade” Grade fibrosis – “Stage”
Slide 7 : www.tissuepathology.com Patterns of Liver Injury Necroinflammatory Acute Chronic Fat accumulation Macrovesicular Microvesicular Steatohepatitis Cholestasis Acute Chronic Vascular diseases Fibrosis & cirrhosis Specific infections Granulomas Storage diseases Malformations Neoplasms
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