EXHALED NITRIC OXIDE CONCENTRATION IN PATIENTS AFTER HEART TRANSPLANTATION. Ppt Powerpoint Presentation slides Nadziakiewicz Medical Slideshow of inhaled nitric oxide in patients with the acute respiratory distress syn

EXHALED NITRIC OXIDE CONCENTRATION IN PATIENTS AFTER HEART TRANSPLANTATION.

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Slide 1 :

EXHALED NITRIC OXIDE CONCENTRATION IN PATIENTS AFTER HEART TRANSPLANTATION. 1 Pawel Nadziakiewicz,1 Piotr Knapik, 2 Michal Zakliczynski , 2 Marian Zembala, 1 Ewa Urbanska, 2 Jerzy Pacholewicz , Dept. of Cardiac Anesthesia, Silesian Center for Heart Diseases, Zabrze, Dept. of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Zabrze,

Slide 2 :

Facts Nitrc Oxide (NO) is present in exhaled air in humans. Exhaled nitric oxide (eNO) is mainly produced by the endothelial cells in the airways and alveoli and only a small portion by pulmonary vessels Patients with heart disease may have decreased levels of exhaled end tidal nitric oxide (FENO) We do not know how administration of cyclosporine affect FENO

Slide 3 :

Aim of the study We wanted to compare the exhaled nitric oxide concentrations between patients after heart transplantation with immunosuppresive therapy based on cyclosporine and healthy volunteers.

Slide 4 :

Patients We examined 32 male participants: Group I – 17 male patients after heart transplantation Group 2 – 15 non-smoking healthy men No infection, chronic lung disease, smoking habit and the use of inhalational medications

Slide 5 :

Medications Patients in group I were taking: cyclosporine A in the mean dose of 217.3 mg/d azathioprine dose 50-100mg/d (7) prednisone dose 20-70mg/d (10) Additonal medications in this group consisted of: calcium blockers (7) ACE inhibitors (7) statins (7) Beta blokers (2) Patients in group 2 did not take any medications

Slide 6 :

Demographic data

Slide 7 :

Methods Exhaled NO was assessed by means of high resolution chemiluminescence analyzer (280 NOA, Sievers, Boulder, Colorado, USA) End tidal concentration from single breath curve was analysed The mean value from six measurements was calculated Measurements were performed according to the recommendations of the European Respiratory Society (1997)

Slide 8 :

Methods Exclusion of nasal nitric oxide was done by exhalation against mouthpiece pressure 10 cm H2O to ensure velum closure. The flow rate of 200ml/s was achieved by the placement of expiratory resistances in the exhalation circuit and by asking the subject to exhale at a constant mouth pressure, which was displayed and readily visualized by the subject on a computer screen

Slide 9 :

Measurement

Slide 10 :

Statistical analysis All data are shown as mean and standard deviation. The data distribution was analyzed by means of Kolmogorow-Smirnow test. Depending on the results, data were analyzed by t-Student test for repeated measurements or Wilcoxon test. Differences between groups were analyzed by t-Student test for independent samples or Mann-Witney test. p < 0.05 was considered significant.

Slide 11 :

ResultsMean FENO concentrations

Slide 12 :

Conclusions Exhaled nitric oxide concentration is not affected by heart transplantation and Use of immunosuppressive therapy based on cyclosporine have no influence.

	nadzial@poczta.onet.pl 1 Years ago. Category: Cardiac transplantation

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