Imaging of dopamine transporters and D2 receptors in vascular parkinsonism a report of four cases Ppt Powerpoint Presentation slides Anonymous Medical Slideshow Decreased dopamine D2 receptor availability is associated with reduced fron

Imaging of dopamine transporters and D2 receptors in vascular parkinsonism a report of four cases

Rating :

Rate It:

Send This

Download

Comment

Favourite

more

Post To:

Facebook

Twitter

Digg

Delicious

more share options

There is no comments now for this Slide.

Post a comment

Post Comment on Twitter Post Comment on SlideWorld

Comments:

Subscribe to follow-up comments

Notes

Show Notes

Slide 1 :

Imaging of dopamine transporters and D2 receptors in vascular parkinsonism: a report of four cases Plotkin M, Amthauer H, Quill S, Marzinzik F, Klostermann F, Klaffke S, Kivi A, Gutberlet M, Felix R, Kupsch A 1 Clinic for Nuclear Medicine2 Clinic for Neurology Charité Universitätsmedizin Berlin, Germany J Neural Transm 2005; 112: 1355-1361

Slide 2 :

We report four patients with the clinical diagnosis of vascular parkinsonism according to Winkantes and Jankovic (1999), in whom SPECT of DAT and D2 receptors showed striking atypical patterns, that were not compatible with known neurodegenerative parkinsonian syndromes Patients

Slide 3 :

A 67-year-old female patient with L-DOPA-nonresponsive hypokinetic-rigid syndrome. FP-CIT SPECT (A) demonstrates a normal DAT binding in both basal ganglia. The D2 receptors are clearly reduced in the right striatum and absent in the left striatum (IBZM-SPECT, B). The FLAIR MRI demonstrates multiple T2-hyperintensive vascular lesions in both frontal lobes (arrowheads) as well as small hemosiderin deposits in the left thalamus and right putamen, indicative of older infarcts (C, arrows) A B C IBZM SPECT FP-CIT SPECT MRI Case 1

Slide 4 :

A B C IBZM SPECT FP-CIT SPECT MRI Case 2 A 83-year-old female patient with a 5-years history of parkinsonism in whom an old lacunar capsula interna-infarction was detected by MRI (C, arrow). The L-DOPA test was initially positive, but no significant relief of symptoms could be achieved by a long-term medication. FP-CIT SPECT (A) shows a clearly reduced DAT in both basal ganglia with a pronounced affection of the putamina. IBZM SPECT (B) demonstrates intact D2 receptors in the right striatum, but severe reduced D2 receptor binding in the left striatum. In this case, a combination of IPS with a VP was supposed

Slide 5 :

The role of nuclear medicine imaging in the diagnosis of vascular parkinsonism (VP) has been addressed by only few studies up to now. Most previous reports suggest no or only mild impairment of DAT and D2 receptors in VP. In contrast, in four patients with VP, reported here, the combined DAT and D2 receptor SPECT showed highly unusual changes in the pre- and/or postsynaptic dopaminergic system. The possible value of combined DAT/D2 receptor SPECT imaging should be investigated by future prospective studies Summary

	SlidesOnline 1 Years ago. Category: Pathology

Tags:	Pathology

Embed:
123 Views, 0 favourite
PowerPoint Presentation on Imaging of dopamine transporters and D2 receptors in vascular parkinsoni more PowerPoint Presentation on Imaging of dopamine transporters and D2 receptors in vascular parkinsonism a report of four cases or PowerPoint Presentation on less

SWINE Flu

Why do women live longer then men? Humor

History of Medicine

Yoga and Medicine

How to be a Successful Interventional Fellow size 50 MB

Cardiac Pathology

Hypertension: New Concepts, Guidelines, and Clinical Management

Diabetes Pathology

Medical Powerpoint Templates
(20% Dicsount For Student/Faculty)