Juvenile rheumatoid arthritis


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steve    on Sep 27, 2011 Says :

The rare disease is well covered
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1 : Juvenile rheumatoid arthritis
2 : Overview Juvenile rheumatoid arthritis (JRA) is a general term for the most common types of arthritis in children. It is a long-term (chronic) disease resulting in joint pain and inflammation, which may lead to joint damage.
3 : Symptoms *Joint stiffness on arising in the morning *Limited range of motion & Back pain *Slow rate of growth or uneven arm or leg growth *Hot, swollen, painful joints *A child may stop using an affected limb *Fever, usually high fevers every day *Rash that comes and goes with the fever *Swollen lymph nodes (glands) *Red eyes & Eye pain *Photophobia (increased pain when looking at a light) *Visual changes
4 : Treatment *Nonsteroidal anti-inflammatory drugs (NSAIDs) *Corticosteroids *An antimalaria medicine called hydroxychloroquine, which helps reduce inflammation related to JRA *Disease-modifying anti-rheumatic drugs (DMARDs), including methotrexate *Biologic drugs, such as such as etanercept and infliximab, which block high levels of inflammatory proteins Medicines used to treat this condition may include:
5 : Causes *Systemic JRA occurs in about 10% of cases. It involves joint pain, swelling, fevers, and rash. It is similar to adult Still's disease. The cause of this form of JRA is unknown. *Polyarticular JRA occurs in about 40% of cases and involves multiple painful, swollen joints. The cause of this form of JRA is also unknown. Some children may have a positive rheumatoid factor and the condition may turn into rheumatoid arthritis. *Pauciarticular JRA occurs in about 50% of cases and involves only a few joints. Some of these children, in particular boys, will be HLA-B27 positive. HLA-B27 is a substance called a gene marker that is associated with several autoimmune disorders. JRA occurs in 50-100 per 100,000 children in the United States. It usually occurs before age 16.JRA is divided into several categories:
6 : Tests & diagnosis *CBC*ESR (sedimentation rate) *ANA & RA factor & HLA antigens for HLA B27 *X-ray of a joint & X-ray of the chest *ECG & Eye exam by an ophthalmologist The physical examination shows swollen, warm, and tender joints that hurt to move. The child may have a rash. Other signs include an enlarged liver, enlarged spleen, or swollen lymph nodes. Blood tests may include:
7 : Prognosis JRA is seldom life threatening. Long periods of spontaneous remission are typical. Often, JRA improves or goes into remission at puberty. Approximately 75% of JRA patients eventually enter remission with minimal functional loss and deformity. For additional information and resources, see arthritis support group.
8 : Prevention There is no known prevention for JRA.
9 : Complications *Total joint destruction of the major weight-bearing joints *Loss of vision or decreased vision *Chronic spondyloarthropathy (back stiffness)
10 : When to contact a doctor Call for an appointment with your health care provider if you notice symptoms of juvenile rheumatoid arthritis. Also call your health care provider if your symptoms get worse, do not improve with treatment, or if new symptoms develop.

 

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Juvenile rheumatoid arthritis
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