Learning Dopamine Theta rhythm Ppt Powerpoint Presentation slides Holger Stark Medical Slideshow Theta Dopamine

Learning Dopamine Theta rhythm

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Slide 1 :

Slide 2 :

Microdialysis > prefrontal dopamine (EEG over medial prefrontal cortex) Mongolian gerbil (Meriones unguiculatus) Conditioned tone stimulus Unconditioned footshock via grid floor Compartment change after footshock > escape response click Compartment change after tone > avoidance response

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slow improvement of performance strong improvement of performance strong, transient increase of dopamine constant high performance Signal detection: tone > signal Signal evaluation: learning of escape and avoidance response Retrieval of avoidance strategy click

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Tone Footshock Signal detection: tone > signal Signal evaluation: learning of escape and avoidance response Retrieval of avoidance strategy Attention response Reaction time Dopamine content Conditioned avoidance response First attention response Unconditioned escape response Conditioned avoidance response Basal dopamine Reaction time of the first trial Dopamine of the first trial Dopamine post stimulation 1 2 3 click

Slide 5 :

Tone Footshock unconditioned response RECORDING OF EEG-EPISODES 1 TO 15 s AFTER CHANGE OF SHUTTLE-BOX COMPARTMENT DURING AVOIDANCE CONDITIONING s Theta activity after compartment change Sessions with 60 tone-footshock combinations (trials) 10 20 30 40 50 60 Trials 0 5 Theta activity after compartemnt change conditioned response Frequency (Hz) Theta power Comparison between plan and result of action > feedback and error processing EEG click compartment change

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Trial 5 Trial 6 Trial 30 Trial 32 Trial 61 Signal evaluation: Signal tone > escape and avoidance learning Escape response Avoidance response Retrieval of avoidance strategy Normalized theta power Reaction time (s) Accumulated conditioned responses Signal-detection: tone > signal click

Slide 7 :

Activity of prefrontal dopamine system and theta activity > intensity of formation of associations in defined stages of a learning process Trial-specific theta activation during avoidance learning > discrete transitions of stages 1. Signal detection 2. Escape learning 3. Avoidance learning 4. Retrieval of avoidance strategy Learning dependent investigations to elucidate principles of internal reinforcement (reward / motivation) during development of memory-guided behavioral strategies click Thank you for your attention

	stark@ifn-magdeburg.de 1 Years ago. Category: Neurology

Tags:	Neurology

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