MELAS syndrome

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Slide 1 :

MELAS Syndrome: the role of the otologist Petros Karkos, AFRCSI Murray Waldron, FRCS Ian Johnson, FRCS

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MELAS M itochondrial cytopathy E ncephalopathy LA ctic acidosis S troke-like episodes AND… SNHL

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WHY? Early diagnosis Succesful Rehabilitation

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PATHOPHYSIOLOGY A POINT MUTATION of mt-DNA > 16 in 100,000 ATROPHY OF THE STRIA VASCULARIS

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CLINICAL FEATURES CARDINAL FREQUENT( SNHL) OTHER SNHL is frequent (44-75%) ( Hirano et al, Chinnery et al)

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DIAGNOSIS HIGH INDEX OF SUSPICION COMBINATION OF FEATURES: Myopathy& CNS involvement GENETIC TESTS: A3243G mutation MUSCLE Bx: ragged-red fibres

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TREATMENT MULTIDISCIPLINARY Tx: 1)GUIDANCE ABOUT THE FUTURE 2)REGULAR F.Ups 3)INTERVENTION ANAESTHETIC CONSIDERATIONS

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HEARING LOSS

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CONCLUSION ALL MELAS MUST BE SCREENED ALL MELAS MUST BE FOLLOWED UP OTOLOGIST NEEDS TO BE PART OF THE MELAS TEAM

Acute Coronary Syndr...

The Long QT Syndrome...

Paclitaxelinduced ac...

Treatment of steriod...

Concordance of stand...

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	pkarkos@aol.com 4 Years ago.



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