MELAS syndrome Ppt Powerpoint Presentation slides Peter D Karkos Medical Slideshow East Melas Chasma: Insight into Valles Marineris

MELAS syndrome

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Slide 1 :

MELAS Syndrome: the role of the otologist Petros Karkos, AFRCSI Murray Waldron, FRCS Ian Johnson, FRCS

Slide 2 :

MELAS M itochondrial cytopathy E ncephalopathy LA ctic acidosis S troke-like episodes AND… SNHL

Slide 3 :

WHY? Early diagnosis Succesful Rehabilitation

Slide 4 :

PATHOPHYSIOLOGY A POINT MUTATION of mt-DNA > 16 in 100,000 ATROPHY OF THE STRIA VASCULARIS

Slide 5 :

Slide 6 :

CLINICAL FEATURES CARDINAL FREQUENT( SNHL) OTHER SNHL is frequent (44-75%) ( Hirano et al, Chinnery et al)

Slide 7 :

DIAGNOSIS HIGH INDEX OF SUSPICION COMBINATION OF FEATURES: Myopathy& CNS involvement GENETIC TESTS: A3243G mutation MUSCLE Bx: ragged-red fibres

Slide 8 :

TREATMENT MULTIDISCIPLINARY Tx: 1)GUIDANCE ABOUT THE FUTURE 2)REGULAR F.Ups 3)INTERVENTION ANAESTHETIC CONSIDERATIONS

Slide 9 :

HEARING LOSS

Slide 10 :

CONCLUSION ALL MELAS MUST BE SCREENED ALL MELAS MUST BE FOLLOWED UP OTOLOGIST NEEDS TO BE PART OF THE MELAS TEAM

	pkarkos@aol.com 1 Years ago. Category: Otolaryngology

Tags:	Otolaryngology

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