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Medical Applications of Nanotechnology

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sasikala k on Aug 31, 2009 Says :

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Show Notes

Slide 1 :

Medical Applications of Nanotechnology Timothy E. Morey, M.D. Associate Professor of Anesthesiology University of Florida

Slide 2 :

How small is nano? E. Corcoran. The Next Small Thing. Forbes Magazine, 07/23/01

Slide 3 :

Nanotechnology Growth S. Milunovich, J. Roy. United States Technology Strategy. Merrill Lynch. 4 Sept. 2001

Slide :

Slide 5 :

NanoMedical Diagnostics Targets: - drug overdose - brain trauma - disease markers Where: - hospital - law enforcement - homeland security

Slide 6 :

Why the University of Florida? Comprehensive university on a compact campus Institutional support and priority (2002) “…biotechnology, particularly at the interface of medicine and nanoscience.” Interdisciplinary faculty with critical mass and focus Active OTL partner with a biotechnology incubator

Slide 7 :

NanoMedical Research Center Vision: Create and harness nano-structured material technologies for the prevention, detection and treatment of diseases in order to enhance the public health and to expand the Florida and national economies Focus: Develop nanostructures for medical diagnostics and therapeutics Funding: State of Florida Centers of Excellence $19.9 million for FY2003-07 with milestones Product: Knowledge / Publications / Translational Science Prototypes and IP for OTL licensure

Slide 8 :

Additional Slides to Answer Questions

Slide 9 :

MIT Institute for Soldier Nanotechnologies Vision: lighter, faster, more agile force using nanotech. Focus: use nanotechnology to dramatically improve the survival and lethality of soldiers Faculty: 40 faculty in eight academic departments >100 students and postdocs 11 supportive staff members Funding: United States Army 5 year, $50 million grant beginning FY2002 Product: create a battlesuit that combines high-tech capabilities with light weight and comfort

Slide 10 :

What is nanotechnology Creation of functional materials, devices, and systems. Control of matter on the nanometer (1-100 nm) length scale. Exploitation of novel properties and phenomena developed at that scale.

Slide 11 :

Slide 12 :

What is nano?

Slide 13 :

Why is the nanometer scale different? The wavelike properties of electrons inside matter are influenced by variations on the nanometer scale. The systematic organization of matter on the nanometer length scale is a key feature of biological systems. Nanoscale components have very high surface areas. The finite size of material entities, determine an increase of the relative importance of surface tension and local electromagnetic effects. The interaction wavelength scales of various external wave phenomena become comparable to the material entity size.

Slide 14 :

"There's plenty of room at the bottom." Richard P. Feynman, Ph.D.

Slide 15 :

Nanotechnology Applications stain resistant textiles information recording layers adaptive camouflage body armor high hardness cutting tools chemical and bio-detectors advanced drug delivery systems

Slide 16 :

Who else is interested? Rensselaer Polytechnic Institute (Troy, NY) focus on physical nanotechnology Rice University (Houston, TX) focus on environment and carbon nanotubes Cornell University (Ithaca, NY) origins in materials engineering University of Michigan (Ann Arbor, MI) invested in therapeutics

Slide 17 :

Why Florida?

Slide 18 :

Why Nano-Medical in Florida? Targets key industries in Florida Pharmaceuticals Analytical Instruments Medical Devices 3 of the 10 highest wage Florida industries 3 times as many jobs exist in these industries as in Florida’s IT industries Florida – Profile of the State Economy; M. Porter; Harvard Business School; Prepared for Gov Bush; 2002

Slide 19 :

State of Florida Center of Excellence State of Florida $30 million for 2-5 Centers of Excellence Grants solicited in 2002 for FY2003 commencement NanoMedical Research Center Focused on nanomedical therapeutics and diagnostics Collaboration of chemists, engineers, medical researchers Requested $20 million Ranked 3rd of 16 applicant centers Awards: UCF, UF (regenerative medicine), FAU

Slide 20 :

UF Strategic Plan: Priority Areas Cancer and Genetics Research on the Brain Biotechnology – Interface of Medical Science and Nanoscience Aging Children and Families Ecology/Environment

Slide 21 :

UF Unique Capabilities - Programs

Slide 22 :

Deliverables Pipeline Pesticide detoxification Drug detox Bacteriorhodopsin-based data storage Microemulsion formulation technology Biophotonics-based detection of disease Nanoengineered pulmonary drug delivery systems Knowledge of bio-nano toxicity Nanosensors for management of traumatic brain injury Smart nanostructures for targeted drug delivery 2003 2005 2009 2004 2006 2007 2008 Breath detection of drugs Breath detection of diseases Flexible device/system integration Deliverables Chip-based drug delivery system

Slide 23 :

Milestones: Diagnostics Incorporate reporter molecule into nanotubes Decorate surface with appropriate targeting Couple target recognition with uncapping Detect reporter molecule in blood and breath Use in diseased animal model Use in cells lines of cancer

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“…biotechnology, particularly at the interface of medicine and nanoscience.Florida – Profile of the more “…biotechnology, particularly at the interface of medicine and nanoscience.Florida – Profile of the State Economy; M. Porter; Harvard Business School; …www.anest.ufl.edu/nanomed/Nanotalk.ppt less

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