Microbiology and Immunology

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Slide 1 :

Program Coordinator: Laura Kasman, Ph.D. kasmanL@musc.edu

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M&I program currently 17 Ph.D. students 4 MD/Ph.D. students 1 DMD/Ph.D. student 2 Masters students 15 Departmental faculty 40 Total Program faculty

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Program Requirements 6 credits in advanced M&I courses in 2nd year Written qualifying exam, summer after 2nd year Thesis proposal defense, usually sometime in 3rd year for admission to candidacy 12 advanced credits total, not including M&I Seminar

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M&I Advanced course offerings

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Departmental vs. Program Faculty Department Faculty have M&I as their home department M&I Program Faculty can be faculty members from any MUSC department that have research interests related to microbiology or immunology Faculty can be affiliated with more than one graduate program

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M&I Department Faculty Interests

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Bacteriologists Michael Schmidt Hal May Ed Balish

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Virologists Natalie Sutkowski John Y. Dong Laura Kasman

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Immunologists Janardan Stephen Gabriel Aziz Carl Pandey Tomlinson Virella Haque Atkinson Also Natalie Sutkowski

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Tumor Immunologists & Gene Therapy James Norris Christina Xiang Liu Semyon Voelkel-Johnson Rubinchik Also Stephen Tomlinson & John Dong

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Program Faculty Surgery Prabhakar Baliga Mike Nishimura Kenneth Chavin David Cole Yi Zhang Pathology Amanda LaRue Otolaryngology Rita Young Neurosciences/Neurology Narendra Banik Narayan Bhat James Cook William Tyor Swapan Ray Pediatrics Inderjit Singh Isabel Virella-Lowell

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Program Faculty College of Dental Medicine Robert Boackle Caroline Westwater Radiation Oncology Sebastiano Gattoni-Celli College of Pharmaceutical Sciences Craig Beeson Cell Biology & Anatomy Titus Reaves Rheumatology James Oates Maria Trojanowska Gary Gilkeson Biochemistry Greg Warr Maurizio Del Poeta Division of Infectious Disease Christopher Parsons

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Entrepreneurship by M&I faculty

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MOUNT PLEASANT, SC (AUGUST 30, 2007) - Groundbreaking ceremony for new facility at Innovation Park, in the economic development zone of The Market at Oakland. GenPhar, Inc. is a biopharmaceutical company dedicated to providing vaccines that protect against infectious diseases with great socio-economic impacts worldwide. Biodefense programs: GenPhar's vaccine platform is ideally designed for biodefense because one vaccine can prevent infection from multiple virus subtypes.

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James S. Norris, PhD Co-Founder, SphingoGene, Inc. http://www.sphingogene.com Professor and Chairman, MUSC norrisjs@musc.edu SphingoGene, Inc. SphingoGene, Inc. is focused on commercialization of small molecule therapeutics that modify ceramide metabolism to overcome resistance to chemo and radiation therapy and promote apoptosis in cancer cells. Ceramide is a “tumor suppressor sphingolipid” involved in regulation of cell death. SphingoGene, Inc.’s molecules are rationally designed and proven to inhibit enzymes that create resistance to conventional cancer therapies. Our goal is to utilize these small molecules in combination with “standard of care” radiation or chemotherapy to enhance cancer cell death. Commercial Lipidomic Services Molecular diagnostic to predict patient Response Combination therapy for standard of care Therapies in cancer patients (chemo, radiation and gene therapy Products and Services

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Controlling Inflammation to Treat Human Disease Applying novel technologies to create better treatments Contact: Woodruff Emlen MD wemlen@taligentherapeutics.com Taligen Therapeutics, Inc. is a development stage biotechnology company with novel technology to modulate and regulate activation of the complement system. Inappropriate complement activation leading to inflammation is a major contributor to a large number of human diseases. Taligen has proof of concept data in animal models of diseases as diverse as asthma, macular degeneration, immune renal disease, inflammatory arthritis, ischemia-reperfusion injury, stroke and traumatic brain injury. Product Development Currently focused on the areas of asthma and age related macular degeneration. Stephen Tomlinson, PhD Professor tomlinss@musc.edu

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Dr. Hal May, Ph.D. VP, MFC Technologies LLC http://www.mfctech.net hmay@mfctech.net Assoc. Prof. MUSC mayh@musc.edu Microbially Generated Electricity Increase Biofuel Production 24/7 Remote Power, Sensor Control Control Waste, Odor and Algae

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MFC Tech is focused on the development of microbial fuel cell technology (MFCs), which utilizes the ability of bacteria to generate electricity. Patentable approaches are targeted for the enhancement of waste management and electricity generation, namely… 24/7 remote power generation such as along highways and in retention ponds Development of specific sensors or the powering of sensors in remote locations Enhancement of biofuel production through the application of MFC technology to cellulosic ethanol fermentation The reduction of agricultural waste, odors and algal blooms in waste lagoons and retention ponds

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