Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma Ppt Powerpoint Presentation slides Robert A. Kyle, MD Medical Slideshow Monoclonal Gammopathy of Undetermined Significance (MGUS)

Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma

Rating :

Rate It:

Send This

Download

Comment

Favourite

more

Post To:

Facebook

Twitter

Digg

Delicious

more share options

There is no comments now for this Slide.

Post a comment

Post Comment on Twitter Post Comment on SlideWorld

Comments:

Subscribe to follow-up comments

1 Favorites

opmgdoc, favourited this 3 Months ago.

Notes

Show Notes

Slide :

Slide 2 :

MGUS Olmsted County MN Criteria Serum M-spike < 3.0 g/dL Bone marrow plasma cells <10% if done No evidence of other B-cell disorders No end organ damage

Slide 3 :

MGUSOLMSTED COUNTY, MN RESULTS Olmsted County Residents > 50 years; 28,038 Serum samples obtained from population: 77% Kyle et al., New Engl J Med, 2006, 354:1362

Slide 4 :

MGUS Olmsted County MN CP1118008-35 Age No. No. % 50 – 59 8,373 141 1.7 60 – 69 6,019 178 3.0 70 – 79 4,508 205 4.6 =80 2,563 170 6.6 Total 21,463 694 3.2 = 70 7,071 375 5.3 M-protein Kyle et al., New Engl J Med, 2006, 354:1362

Slide 5 :

Age (yr) Prevalence of MGUS (%) Prevalence of MGUS According to Age Kyle et al., New Engl J Med, 2006, 354:1362

Slide 6 :

MGUS in African Americans White African American N Subjects 3,250,107 749,754 MGUS N, % 1,312 (.40%) 734 (.98%) MM at 10 yrs 15% 17% Langren, et al., Blood, 107:904, 2006

Slide 7 :

MGUSSE MinnesotaJan 1, 1960-Dec 31, 1994 CP1118008-24 Male (%) 54 Age (med years) 72 <40 years (%) 1.7 M-spike (g/dL-med) 1.2 n=1,384 Kyle, et al., New Engl J Med, 346:564, 2002

Slide 8 :

Relative Risk of Progression Obs Exp* RR Multiple Myeloma 75 3 25 Lymphoma, IgM 19 7.8 2.4 Amyloidosis 10 1.2 8.4 Macroglobulinemia 7 0.2 46 CLL 3 3.5 0.9 Plasmacytoma 1 0.1 8.5 Total 115 15.8 7.3 * Iowa SEER Registry MGUSSE MINNESOTA Kyle, et al., New Engl J Med, 346:564, 2002

Slide 9 :

MGUS SE Minnesota1960-1994n=1,384 12% 25% 30% First progression Full progression 10% 21% 26% Cumulative probability (%) Years 1,384 Patientsat risk(no.) 867 423 177 56 17 CP1022686-6 Kyle, et al., New Engl J Med, 346:564, 2002

Slide 10 :

Full Progression or Death CP971723- 6 Cumulative incidence (%) Years 6% Progression Death 10% 11% 53% 72% 76% Kyle, et al., New Engl J Med, 346:564, 2002

Slide 11 :

Relative Risk of Full Progression bySerum M-Spike Size Serum m-spike value CP999081-2 Relative risk of fullprogression Probability of full progressionat 20 years (%) 13.6 15.6 41.2 48.8 24.6 64 Kyle, et al., New Engl J Med, 346:564, 2002

Slide 12 :

MGUS and Free Light Chain (FLC) Rajkumar, et al., Blood; 106:1148, 2005

Slide 13 :

Smoldering Multiple Myeloma Serum M-spike = 3 g/dl and Bone marrow plasma cells = 10% No end organ damage Kyle RA and Greipp PR, NEJM, 302:1347, 1980.

Slide 14 :

Smoldering Multiple Myeloma Mayo Clinic 1970 – 1994 N % Serum M-protein = 3 g/dl and 113 38 Bone marrow plasma cells = 10% Serum M-protein < 3 g/dl and 158 52 Bone marrow plasma cells = 10% Serum M-protein = 3 g/dl and 30 10 Bone marrow plasma cells < 10% TOTAL 301 100

Slide 15 :

Smoldering Multiple Myeloma Time to progression Median years Serum M-spike = 3 Bone marrow plasma 2.2 cells = 10 Serum M-spike < 3 Bone marrow plasma 7.8 cells = 10 Serum M-spike = 3Bone marrow plasma 19 cells < 10 Total (N = 301) p= <0.001 5.5

Slide 16 :

years from diagnosis percent 0 5 10 15 20 25 0 20 40 60 80 100 Progression to Multiple Myeloma or Amyloid 51% 66% 73% 78%

Slide :

	Medslides_PPT 1 Years ago. Category: Internal Medicine

Tags:	Internal Medicine

Embed:
818 Views, 1 favourite
PowerPoint Slide Presentation on Monoclonal Gammopathy of Undetermined Significance and Smoldering more PowerPoint Slide Presentation on Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma less

SWINE Flu

Why do women live longer then men? Humor

History of Medicine

Yoga and Medicine

How to be a Successful Interventional Fellow size 50 MB

Cardiac Pathology

Hypertension: New Concepts, Guidelines, and Clinical Management

Diabetes Pathology

Medical Powerpoint Templates
(20% Dicsount For Student/Faculty)