Pagets disease

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1 : Paget’s disease
2 : Overview Paget's disease is a disorder that involves abnormal bone destruction and regrowth, which results in deformity.
3 : Symptoms *Bone pain (may be severe and persistent) *Bowing of the legs and other visible deformities *Enlarged head *Fracture & Headache & Hearing loss *Joint pain or stiffness & Neck pain *Reduced height & Skull deformities *Warmth of skin over the affected bone
4 : Treatment *Patients with deformities *Patients with no symptoms when certain bones (such as weight-bearing bones) are involved, especially if the bony changes are progressing quickly, to reduce the risk of fractures *Patients with symptoms *Bisphosphonates -- These drugs are the first-line treatment, and they help increase bone density. *Alendronate (Fosamax) & Etidronate (Didronel) *Pamidronate (Aredia) & Risedronate (Actonel) *Tiludronate (Skelid) & Zoledronic acid (Zometa) *Intranasal (Miacalcin) *Subcutaneous (Calcimar) & Plicamycin (Mithracin)
5 : Causes *Arm *Collar *Leg *Pelvis *Spine The cause of Paget's disease is unknown, although it might have to do with genes or a viral infection early in life. The disease occurs worldwide, but is more common in Europe, Australia, and New Zealand. In people with Paget's disease, there is an abnormal breakdown of bone tissue, followed by abnormal bone formation. The new bone is bigger, but weakened and filled with new blood vessels. The disease may only be in one or two areas of the skeleton, or throughout the body. It often involves bones of the:
6 : Tests & diagnosis *Bone scan & Bone x-ray *Elevated markers of bone breakdown (for instance, N-telopeptide) *Elevated serum alkaline phosphatase *ALP (alkaline phosphatase) isoenzyme *Serum calcium Tests that may indicate Paget's disease include:
7 : Prognosis Disease activity and symptoms can generally be controlled with current medications. A small percentage of patients may develop a cancer of the bone called osteosarcoma. Some patients will need joint replacement surgery..
8 : Complications *Bone fractures *Deafness *Deformities *Heart failure *Paraplegia *Spinal stenosis
9 : When to contact a doctor Call for an appointment with your health care provider if you develop symptoms of Paget's disease.


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Pagets disease
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