Persistent Organic Pollutantsreprotox action of mixture

Send This

Download

Comment

Favourite

more

Rating :

Rate It:

Embed :

Post a comment

Post Comment on Twitter Post Comment on SlideWorld

Comments:

Subscribe to follow-up comments

Notes

Hide Notes

Slide 1 :

Persistent Organic Pollutants- reprotox action of mixture Ewa Gregoraszczuk Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Krakow, Poland

Slide 2 :

create global public health risks because of their toxic effects on health and their environment, their persistence, their ability to bioaccumulate and their long-range (indeed global) transport. The POPs (Persistent Organic Pollutants)

Slide 3 :

POPs Become ubiquitous contaminants of fish, dairy products, and other foods around the world. One or more POPs chemicals are detectable in virtually every living organism, Many people around the world now carry enough POPs in their body fat to raise concern about serious health problems, including reproductive developmental problems, cancer and immune system disruption.

Slide 4 :

Endocrine disrupting chemicals –Definitions Endocrine Disruptor Exogenous substance or mixture that alters the function(s) of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny, or (sub)populations Potential Endocrine Disruptor Exogenous substance or mixture that possess properties that might be expected to lead to endocrine disruption in an intact organism, or its progeny, or (sub)populations

Slide 5 :

Specialty Areas in Toxicology • Target Organ/System. – Neurotoxicology, Genetic Toxicology, - Reproductive Toxicology, Immunotoxicology, Endocrine Toxicology. • Target Species/Systems. – Aquatic Toxicology, - Environmental Toxicology, - Wildlife Toxicology, Veterinary Toxicology. • Selected Responses. – Teratology, - Carcinogenesis.

Slide 6 :

Factors Influencing Toxicity Additive 2 + 2 = 4 • Synergistic 2 + 2 = 10 • Potentiation 2 + 0 = 6 Antagonism 2 +2 = 0

Slide 7 :

Reproductive Toxicity?? Any adverse effect on any aspect of male or female sexual structure, function, and lactation including effects on the reproductive potential and viability of the offspring General Mechanism - Synthetic and naturally occurring compounds that can adversely affect the normal hormonal homeostasis and functions in animals. - Androgenic: act like an androgen - Estrogenic: act like estrogen - Antiandrogenic: suppress androgen - Antiestrogenic: suppress estrogen

Slide 8 :

Female Reproductive Toxicants:EDCs In humans, estrogenic compounds ? alter natural hormone cycles ? are associated with breast cancer induction ? may function as promoters or inducers of carcinogenesis

Slide :

Effect of Vit E and/...

DChiroInositol and i...

Effects of occupatio...

Halogenated Volatile...

Ethics and humanitar...

Free Powerpoint Templates

	ewa.gregoraszczuk@uj.edu.pl 5 Years ago.



1058 Views, 0 favourite
PowerPoint Slide Presentation on
More By User Flag as inappropriate Select your reason for flagging this presentation as inappropriate. If needed, use the feedback form to let us know more details. Cancel