Ratecoding of spinal motoneurons with high frequency magnetic stimulation of human motor cortex.

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Slide 1 :

Rate-coding in Spinal Motoneurons with High Frequency Magnetic Stimulation of Human Motor Cortex P. Bawa, B Calancie. Can J Physiol Pharm. 82: 740-748, 2004

Slide 2 :

C.S. Sherrington motoneuron and motor unit R.E. Burke Motor unit properties E. Henneman The size principle Anaesthetised / decerebrate cats

Slide 3 :

Recruitment & Rate Coding in Humans Landmark papers on normal humans, using voluntary cortical input to the motoneurons, was done by Dick Stein and is coworkers in Edmonton. In addition to establishing the size principle of MU recruitment, they also established rate coding and recruitment in the control of movement ( Journal of Physiology, 1973)

Slide 4 :

Transcranial magnetic stimulation Single stimulus pulses applied to a transcranial magnetic stimulator recruit motoneurons according to size principle (Bawa and Lemon, J Physiology, 1993) High frequency trains applied to the motor cortex of baboons showed potentiation of responses of spinal motoneurons Phillips and Porter (1964)

Slide 5 :

METHODS We studied the firing patters of human motoneurons when high frequency stimulus trains were applied to the motor cortex

Slide 6 :

High Frequency Transcranial Magnetic Stimulation of the motor cortex m@n stimulus train Number of pulses in the train, m = 2, 3, 4 Interpulse interval n = 1- 6 ms Four MAGSTIM 200s connected in series by 3 BiStim Modules

Slide 7 :

RESULTS Surface EMG As the number of pulses in the stimulus train increased, area under the response peak increased. Figure on the right shows rectified and averaged surface EMG from tibialis anterior muscle for 1, 2 and 4-pulse trains.

Slide 8 :

Three Pulse Trains

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Double Discharges

Slide 10 :

Double discharges in tibialis anterior

Slide 11 :

Summary of Results A high frequency stimulus train applied to the motor cortex results in facilitation of the motor output During this facilitation, the motoneuron demonstrates rate coding: (2) by responding with double discharges (1) by responding more frequently with single pulses

Slide 12 :

In humans, spinal motoneurons are capable of following the extremely high firing rates associated with corticomotoneurons These extremely high rates or short interspike intervals are important for maximizing the force F and dF/dt at the onset of a contraction Conclusions

Slide 13 :

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	bawa@sfu.ca 5 Years ago.



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