TCA cycle

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Slide 1 : Ramesh V Department of Biochemistry SRMC & RI TCA CYCLE
Slide 2 : Discovered by Hans Krebs in 1937. Intra cellular location: Mitochondria matrix Acetyl units are oxidized to CO2 Totally 8 steps. Krebs cycle or Tricarboxylic acid (TCA) cycle:
Slide 3 :
Slide 4 : Step 1: Formation of citrate Enzyme: Citrate synthase
Slide 5 : Enzyme: Aconitase Dehydration Hydration Step 2: Formation of Isocitrate
Slide 6 : Step 3: Formation of a-Keto glutarate 1st NADH produced 1st CO2 removed NAD+ is reduced to NADH one C is removed as CO2. Enzyme: Isocitrate dehydrogenase
Slide 7 : Step 4: Oxidative Decarboxylation of a-Keto glutarate 2nd NADH produced 2nd CO2 removed Enzyme: a-kG dehydrogenase
Slide 8 : Enzyme: succinyl CoA synthetase. It is an example for substrate level Phosphorylation. GTP + ADP ? GDP + ATP (NPTase) Step5: Formation of succinate
Slide 9 : Enzymes: Succinate Dehydrogenase, Fumarase, Malate dehydrogenase.. Succinate Dehydrogenase is only enzyme of the TCA cycle present on the inner mitochondrial membrane rather than in the matrix. Here, Oxaloacetate regenerated by oxidation of succinate Steps 6 - 8
Slide 10 : Overall reaction: Acetyl CoA + 3NAD+ + FAD + GDP + Pi + 2H2O 2CO2 + CoA + 3NADH + FADH2 + GTP + 3H+
Slide 11 : Citric Acid Cycle: Overview Input: 2-carbon units Output: 2 CO2, 1 GTP, & 8 high-energy electrons
Slide 12 :
Slide 13 : Inhibitors: 1.Fluoroacetate: Inhibits enzyme Aconitase. 2.Arsenite: Inhibits enzyme a-kG 3.Malonate: Inhibits enzyme succinate dehydrogenase.
Slide 14 : Vitamins plays key roles in TCA cycle: 1.Riboflavin 2.Niacin 3.Thiamin 4.Pantothenic acid.
Slide 15 :
Slide 16 : Significance of TCA cycle: 1.It is the final common oxidative pathway 2.Fat is burned on the wick of carbohydrates. 3.TCA cycle is truly amphibolic(catabolic+anabolic). 4.TCA cycle acts as a source of precursors of biosynthetic pathways.
Slide 17 : Regulated primarily by ATP & NADH concentrations, control points: Isocitrate dehydrogenase & ?- kG dehydrogenase Control of citric acid cycle
Slide 18 : Thank you

 


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