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Khushbu    on Aug 14, 2012 Says :

nice PPT on immune system.
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Slide 1 : Immunology Immunology is the study of our protection from foreign macromolecules or invading organisms and our responses to them. Host – e.g. me!!!! Foreign macromolecule, antigen – e.g. virus protein, worm, parasite (Everything that should not be in my body)
Slide 2 : Immunity Defensive mechanism that provides protection against infectious diseases caused by foreign substances introduced into our body by producing a immune response, where immune cells and molecules interact with the foreign invader and destroy them
Slide 3 : The immune system Immune system Anatomic barriers (Intact Skin, Cilia, mucous membranes) Physiological barriers (temperature, pH, Reflexes) Phagocytic Barriers (cells that eat invaders) Inflammatory barriers (redness, swelling, heat and pain) Antigen specificity (Lymphocytes, B cell, T cell NK cell) Diversity Immunological memory Self/nonself recognition
Slide 4 : B cells B-cell Surface bound antibody Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 5 : Antibody secreting B cell Virus killed Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 6 : T cells Two types: Helper T cells (Th): activates other cells Cytotoxic T cells (Tc): can kill other cells T cells can only recognize antigens associated with certain molecules (MHC) Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 7 : Presentation of antigens to T cells Proteins (peptides) from inside the cell are presented by MHC I molecules to Tc cells. Proteins (peptides) from the outside of cells are presented by MHC II molecules to Th cells. MHC I on almost all cells MHC II on specialized antigen-presenting cells Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 8 : Th Tc Virus infected cell, cancer cell Antigen presentig cell MHC II + peptide MHC I + peptide Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 9 : Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 10 : Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 11 : MHC molecules Important to study what parts of a protein that binds to MHC molecules. MHC I binds peptides with 8-10 aa MHC II bind peptides with 12-25 aa Potentials of peptide vaccines Prediction of peptides is important!!!! Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 12 : Cancer The second ranking cause of death after heart disease in the Western world. most organs and tissues in an organism are in balance (death and renewal) cancer cells have no control in growth mechanisms, can expand to a large size producing a tumor Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 13 : HIV and AIDS HIV – Human Immunodeficiency Virus AIDS - Acquired immunodeficiency syndrome HIV virus binds to Th cells and causes the number of Th cells to decrease. When the number of Th cells is too low, you have AIDS. Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 14 : Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 15 : Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 16 : Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de
Slide 17 : Treatment strategies Inhibit different stages of the lifecycle. HIV protease inhibitors. Peptide Vaccines Seminar Winter Semester 2002/2003 Pierre Dönnes pierre@bioinf.uni-sb.de Annette Höglund annette@bioinf.uni-sb.de Andreas Hildebrandt anhi@bioinf.uni-sb.de

 


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