introduction to antibiotics

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Khushbu on Jul 17, 2012 Says :

good presentation with nicely explained figures

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Slide 1 :

Chemotherapy Dr.Jagadeesh Sanganal

Slide 2 :

Introduction

Slide 3 :

Chemotherapy- Pharmacology, Selectively inhibit /destroy specific agents of diseases- bact, viruses, fungi and parasites. Relation – Neoplastic diseases due to anology b/w malignant cells and pathogenic microbes. Term coined – Poul Ehrlich, 1913. Drugs that attack invading organism without harming host cells.

Slide 4 :

Terms Chemotherapeutic agents- Covers A/B, A/V, A/F, A/pro, A/H and A/Neo. Antibiotics-Misnomer Antimicrobials- Selective Toxicity-Ability of AMA to kill an invading organism without harming cells of host.

Slide 5 :

Antimicrobial activity- Ability – react with microbial cell molecules- interferes with growth and multiplication of the m/o (Static) or killing m/o (Cidal ). Bacteriostatic Bactericidal Antimicrobial Spectrum- range of pathogenic organisms. Broad, Narrow

Slide 6 :

Potency- AMA activity per mg/µg. Expressed as MIC, MBC, MAC MIC-Lowest conc of AMA prevents visible growth of m/o when grown against sequentially diminishing drug conc in vitro. Guides selection of AMA that can reach similar conc in vivo . Provides base for comparing the susceptibility of m/o to the other drugs. Factors- Host, methodology, m/o strain It is fixed to particular m/o.

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General mechanism of antimicrobial agents
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