pharmacological actions of epinephrine


×
Rating : Rate It:
 
Post a comment
    Post Comment on Twitter
Comments:  



  Notes
 
 
1 : PHARMACOLOGICAL EFFECTS OF ADRENALINE (EPINEPHRINE) By Ibel .C. Fredy
2 : Adrenergic drugs (sympathomimetics) Direct sympathomimetics They directly act as agonists on alpha and beta receptors Eg:adrenaline,noradrenaline,phenylepinephrine,methoxamine,xylometazoline,salbutamol, Indirect sympathomimetics They indirectly acts on adrenergic neurons to release nor adrenaline which then acts on adrenergic receptors Eg:tyramine, amphetamine Mixed action sympathomimetics They act directly as well as indirectly Eg:ephedrine,dopamine,mephentermine
3 : MAJOR PHYSIOLOGICAL EFFECTS BY ADRENOCEPTOR AGONISTS SMOOTH MUSCLE NERVE TERMINALS HEART BLOOD VESSELS RESPIRATION EYE G.I.T URINARY BLADDER UTERUS C.N.S METABOLISM
4 : Smooth muscle CONTRACTION
5 : Nerve terminals Inhibition C.A release
6 : Heart +ve -Choronotrophy +ve- Ionotrophy
7 : Blood vessels Both vasoconstriction and vasodilatation can occur depending on the drug ,dose and vascular bed Constriction predominates in cutaneous ,mucous membrane, and renal beds By both alpha 1 and alpha 2 receptors Dilatation predominates in skeletal muscle, liver and coronaries
8 : Respiration Adrenaline and isoprenaline are potential vasodilators Adrenaline can directly stimulate R.C but this action is seldom manifest at clinically used doses
9 : EYE Adrenaline causes mydriasis due to contraction of radial muscles of iris(alpha 1)
10 : G.I.T Isolated gut prep… of animals on adr causes relaxation
11 : Bladder Dextrusor is relaxed (beta) and trigone (alpha)is constricted: both these actions results in hindrance of micturition
12 : Uterus Adr can both contract and relax uterine muscles respectively through (alpha) and (beta) receptors. HUMANS: contraction ..
13 : C.N.S Generally no effects ,but restlessness,apprehension,and tremor may occur . Activation of (alpha2) receptor in brain stem results in decreased sympathetic outflow -fall in bp-bradycardia
14 : Metabolic Glycogenolysis Hyperglycaemia Hyperlactacidaemia Lipolysis Inc …in ffa Calorigenesis
15 : Blood pressure Adr given by slow i.v infusion or s.c injection cause rise in systolic but fall in diastolic b.p peripheral resistance decreases because beta 2 receptors are more sensitive than alpha receptors .mean b.p increases .pulse pressure is increased . Rapid I . V injection of adr produces a marked increase in both systolic and diastolic b.p (at high conc in response alpha response predominates and vasoconstriction occurs even at skeletal muscles ).
16 : CAs not absorbed orally. Fate-Metabolism by MAO ( MAO-A in GIT wall) or COMT or both. ADME
17 : CVS- Palpitation tachycardia arrhythmias hypertension cerebral hemorrhage ADR’s Local necrosis gangrene CNS Anxiety fear nervousness tremors restlessness headache dizziness insomnia
18 : Therapeutic uses Cardiac resuscitation, Anaphylactic shock. Combined with local anesthetic to prolong its effect. It is used to control hemorrhage, in dental practice. In bronchial asthma
19 : Marketed products
20 :
21 :

 

Add as Friend By : ibel fredy
Added On : 2 Years ago.
this is a presentation on pharmacological actions of epinephrine
Views 1169 | Favourite 0 | Total Upload :2

Embed Code:

Flag as inappropriate


Related  Most Viewed



Free Powerpoint Templates



 



Free Medical PowerPoint Templates | Powerpoint Templates | Tags | Contact | About Us | Privacy | FAQ | Blog

© Slideworld