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therapeutic options in acute renal failure
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1 Favorites
paogag
, favourited this 3 Years ago.
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Slide 1 :
Therapeutic options in ARF Dr Salwa Ibrahim,MD MRCP Cairo University 24/5/07
Slide 2 :
Incidence Incidence of ARF 50-100 new cases /year/pmp Hospital acquired ARF 2-5% of Admissions 23 % of ICU admissions
Slide 3 :
ARF in “critically ill patients”, severe CVS, respiratory and metabolic instability, sepsis…multiple organ dysfunction ARF in ICU
Slide 4 :
Mortality in ARF Liano et al, 1996
Slide 5 :
Classification system for AKI
Slide 6 :
Slide 7 :
Indications for RRT in critically ill ARF patients
Slide 8 :
Prophylactic Dx in ARF (traumatic) Conger et al, 1975
Slide 9 :
RRT MODALITIES
Slide 10 :
Intermittent Hemodialysis
Slide 11 :
Peritoneal Dialysis
Slide 12 :
CCRT 1977, Kramer described CAVH
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SCUF
Slide 19 :
CRRT vs. IHD Ronco C, 2001
Slide 20 :
Hemodynamics during HD and CVVH
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CRRT: Removal of inflammatory mediators De Vriese A, et al 1999
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8-12 hours Dialysate flow 100-300 ml/m UFR variable BFR 100-300ml/m SLED/EDD (Hybrid therapy)
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SLED/EDD Beth Israel Medical Center (NY) University of Arkansas for medical services University of California at Davis Medical school hospital, Hannover Middlemore hospital, Auckland University of Parma, Italy
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Modality IHD vs. CRRTDose of RRTTiming of RRTSeverity of illness
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CRRT vs. IHD in ARF Mehta et al, 1996
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CRRT vs. IHD in ARF Sandy et al, 1998
Slide 34 :
CRRT vs. IHD in ARF Augustine et al, 2004
Slide 35 :
Effect of severity of illness on mortality in the intermittent hemodialysis and continuous renal replacement therapy groups. Mehta et al, Kidney International, 2001 543 282
Slide 36 :
CRRT vs. IHD
Slide 37 :
The Lancet 2006; 368:379-385Continuous VVHDF Vs, IHD for ARF in patients with MODS: a multicentre randomised trial Findings Rate of survival at 60-days did not differ between the groups (32% in the IHD group versus 33% in CRRT group). Vinsonneau C, et al
Slide 38 :
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www.nature.com/clinicalpractice/neph
Slide 40 :
DOSE OF RRT
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Frequent dialysis is required for hypercatabolic patients C BUN 60 mg/dl B BUN 80 mg/dl A BUN 100 mg/dl Clark, WR et al J Am Soc Nephrol 1997
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Timing Of Initiation of RRT
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Summary Overall prognosis is poor in MODS Mortality linked to number of failing organs 2 organs….60% mortality 3 organs….92%mortality Uncertainty about the best modality
Slide 49 :
Summary Treatment should be individualized Patient factors (catabolic state, hemodynamics) Hospital facilities, knowledge and training of nursing staff, cost
Slide 50 :
Thank You
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