therapeutic options in acute renal failure


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Slide 1 : Therapeutic options in ARF Dr Salwa Ibrahim,MD MRCP Cairo University 24/5/07
Slide 2 : Incidence Incidence of ARF 50-100 new cases /year/pmp Hospital acquired ARF 2-5% of Admissions 23 % of ICU admissions
Slide 3 : ARF in “critically ill patients”, severe CVS, respiratory and metabolic instability, sepsis…multiple organ dysfunction ARF in ICU
Slide 4 : Mortality in ARF Liano et al, 1996
Slide 5 : Classification system for AKI
Slide 6 :
Slide 7 : Indications for RRT in critically ill ARF patients
Slide 8 : Prophylactic Dx in ARF (traumatic) Conger et al, 1975
Slide 9 : RRT MODALITIES
Slide 10 : Intermittent Hemodialysis
Slide 11 : Peritoneal Dialysis
Slide 12 : CCRT 1977, Kramer described CAVH
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Slide 18 : SCUF
Slide 19 : CRRT vs. IHD Ronco C, 2001
Slide 20 : Hemodynamics during HD and CVVH
Slide 21 : CRRT: Removal of inflammatory mediators De Vriese A, et al 1999
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Slide 24 : 8-12 hours Dialysate flow 100-300 ml/m UFR variable BFR 100-300ml/m SLED/EDD (Hybrid therapy)
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Slide 26 : SLED/EDD Beth Israel Medical Center (NY) University of Arkansas for medical services University of California at Davis Medical school hospital, Hannover Middlemore hospital, Auckland University of Parma, Italy
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Slide 30 : Modality IHD vs. CRRTDose of RRTTiming of RRTSeverity of illness
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Slide 32 : CRRT vs. IHD in ARF Mehta et al, 1996
Slide 33 : CRRT vs. IHD in ARF Sandy et al, 1998
Slide 34 : CRRT vs. IHD in ARF Augustine et al, 2004
Slide 35 : Effect of severity of illness on mortality in the intermittent hemodialysis and continuous renal replacement therapy groups. Mehta et al, Kidney International, 2001 543 282
Slide 36 : CRRT vs. IHD
Slide 37 : The Lancet 2006; 368:379-385Continuous VVHDF Vs, IHD for ARF in patients with MODS: a multicentre randomised trial Findings Rate of survival at 60-days did not differ between the groups (32% in the IHD group versus 33% in CRRT group). Vinsonneau C, et al
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Slide 39 : www.nature.com/clinicalpractice/neph
Slide 40 : DOSE OF RRT
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Slide 43 : Frequent dialysis is required for hypercatabolic patients C BUN 60 mg/dl B BUN 80 mg/dl A BUN 100 mg/dl Clark, WR et al J Am Soc Nephrol 1997
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Slide 45 : Timing Of Initiation of RRT
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Slide 48 : Summary Overall prognosis is poor in MODS Mortality linked to number of failing organs 2 organs….60% mortality 3 organs….92%mortality Uncertainty about the best modality
Slide 49 : Summary Treatment should be individualized Patient factors (catabolic state, hemodynamics) Hospital facilities, knowledge and training of nursing staff, cost
Slide 50 : Thank You

 



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