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Ovarian Cancer Scre...

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... a group led by ...

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... a group led by Yale investigators used antibody microarrays to identify four proteins that distinguished ovarian cancer: leptin, prolactin, osteopontin, …

OVARIAN CANCER SCRE...

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They found a patter...

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They found a pattern of 4 specific proteins (IGF II, leptin, osteopontin, and prolactin) had sensitivity and specificity of 95% for OCA. …

Ghrelin Dual endocr...

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Anorexia, cachexia....

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Anorexia, cachexia. Return to normal. Tschöp et al. Diabetes 2001. Caucasians vs. Pima. Lean and obese. BMI, DEXA. Differing levels of insulin and leptin ...

BIOCHEMISTRY OF LEP...

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A tail with 34 a.a ...

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A tail with 34 a.a residues – OB-Ra form . A tail of 32 & 40 a.a –OB-Rc form and OB-Rd form. OB-Re form terminate before transmembrane segment and this …

Adipose Tissue as a...

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Adipose tissue: An ...

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Adipose tissue: An endocrine organ . CRP. IL-6. PAI-1. Angiotensinogen. Leptin. Resistin. MCP-1. TNF-a . Adiponectin . Lau DCW et al. Am J Physiol Heart Circ Physiol. 2005;288 ...

BIOCHEMISTRY OF LEP...

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BIOCHEMISTRY OF LEP...

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BIOCHEMISTRY OF LEPTIN. Shalini Jain and Hariom Yadav. Animal Biochemistry Division. Natioanal Dairy Research Institute. Karnal-132001 (Haryana), India

Understanding Obesi...

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POMC and CART (coca...

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POMC and CART (cocaineand amphetamine regulated transcript) ? ACTIVATED by leptin, INHIBITED by ghrelin . Anabolic cell group: NPY and AgRP

Hypothalamus and Li...

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Anorexigenic factor...

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Anorexigenic factors inhibit eating/appetite: melanocortins ; leptin ; insulin ; PYY . Orexigenic factors stimulate eating/appetite: orexin A, B; NPY; ghrelin

Leptin A Key Player...

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It has been postula...

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It has been postulated that leptin inhibits acetyl-CoA carboxylase ; Enzyme involved in the committed step of fatty acid synthesis; This inhibition leads to decrease in

The Biochemistry of...

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show an association...

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show an association; This may be explained by other causes; Leptin resistance leads to excess Orexin-A which keeps you awake! (and hungry) Obesity is a cause of sleep apnea

Obesity Addiction ...

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Emotional factors. ...

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Emotional factors. Stress, boredom . Intrinsic factors. Leptin, Insulin, Ghrelin, PYY, Dopamine . Hypothalamus . Signals that Control Food Intake

Leptin Replacement ...

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Leptin Replacement ...

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Leptin Replacement Therapy Improves Insulin Resistance in Highly Active Antiretroviralsuppression test), lipid and apolipoprotein levels, lipoprotein particle size, hormone

CHILDHOOD OBESITY T...

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Common obesity due ...

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Common obesity due to multiple allelic variations in hundreds of genes; Monogenic obesity; Leptin deficiency; Leptin insensitivity; RARE

PPT- The cholecyst...

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PPT- Cholecystokini...

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PPT- Cholecystokinin (CCK) Fat cells; Leptin – maintain level of body fat ... Has led to hypothesis that overfeeding infants while hypothalamus is developing may ...

Digestion and Nutri...

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Food molecules are ...

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Food molecules are split by hydrolysis. R-R + H 2 O digestive enzyme R-OHMice that inherit a defect in the gene for the hormone leptin become very obese.

Chapter 12 Hunger, ...

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ob/ob mice are 3X n...

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ob/ob mice are 3X normal weight; Eat more and convert calories to fat more efficiently than controls; Lack leptin, a hormone produced by fat cells

Fatty Acids Recepto...

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FFA 1 R FFA 2 R FFA...

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FFA 1 R FFA 2 R FFA 3 R . Effect . Ligand . Expression . Leptin release . Arrest ofPossible treatment for: Parkinson´s disease, glaucoma, Amyotrophic lateral sclerosis.

PH.Merial.com Pet ...

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Dan W. Moser, Ph.D....

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Dan W. Moser, Ph.D. Department of Animal Sciences and Industry. Kansas State ... Merial igenity L appetite (Leptin) Expect the number of such tests to continue to ...

Genetic basis for N...

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Apo E, SREBP-1c FAB...

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Apo E, SREBP-1c FABP, CETP, LDLR, LPL, LIPC, MTP, Leptin, SCD-1 . Genes involved in hepatic lipid import, storage and export . Adiponectin, HFE, Insulin receptor genes, PPAR ?

LEPTIN Going for th...

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About fifty years a...

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About fifty years ago genetic mutation was discovered which causes massive obesity in mice; In 1994 mutation was characterized as an inactivation of a specific gene

CHILDHOOD OBESITY T...

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leptin nonresponsiv...

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leptin nonresponsiveness is a rare familial cause of obesity in children; Single geneHypothyroidism – TSH, free T4; Cushing’s disease – urinary free cortisol

Role of Leptin in M...

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Effects of leptin i...

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Effects of leptin in peripheral blood in irradiated/BMT mice over time . Saline . Leptin

Among actions of CC...

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Among actions of CC...

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Among actions of CCK which are mediated by the CCK1R, control of satiety, gallbladder contraction, pancreatic exocrine secretion, gastric pepsinogen and leptin secretions

ASTIM ve OBESITE

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Saline . 0,3 . 1 . ...

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Saline . 0,3 . 1 . 3 . 10 . 30 . Saline-PBS . Leptin-PBS . Saline -OVA . Leptin-Ova . Penh . Methacholine mg/ml . Shore S. et al., JACI 2005;115:103-109 . DENEYSEL

PPT- Motivation and...

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PPT- Available glyc...

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PPT- Available glycogen and fat; Eating stops when cued by; a full stomach (short-term) the release of leptin (long-term) Anorexia nervosa and bulimia nervosa

Recap of adiposity ...

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Leptin deficiency c...

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Leptin deficiency causes decreased innervation of the PVN from the arcuate nucleus during development. Leptin repletion during development can rescue this innervation, but

This will be invest...

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This will be invest...

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This will be investigated by studying the effects of cannabinoid receptor ligands on bone mass and bone loss in mice with leptin deficiency (ob/ob) and deficiency of leptin

es/biol4800/rlaine/...

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es/biol4800/rlaine/...

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es/biol4800/rlaine/48007FatCellHormonesAgingAndry1.ppt" classFat Cell Hormones and Aging: Leptin

Leptin receptor (OB...

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RECEPTORJI ZA LEPTI...

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RECEPTORJI ZA LEPTIN (OB-R ali LepR) na “diabetes ... po vezavi leptina se aktivira JAK/STAT ... receptorji posredovan transport (receptor-mediated transport – RMT): leptin ...

Reproductive Biolog...

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REPRODUCTIVE BIOLOG...

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REPRODUCTIVE BIOLOGY. 2008 . Neuroendocrine control of reproduction III . Dr. David Hazlerigg ... Luque et al 2007 Endocrinology 148 . Control . Leptin . Kiss-1 (optical density)



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