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Types of Viral Hepatitis

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Slide 1 :

Types of Viral Hepatitis Hepatitis A - enteric Hepatitis B - parenteral Hepatitis C - parenteral Delta hepatitis - parenteral Hepatitis E - enteric

Slide 2 :

Prevalence of Hepatitis B Virus Infection About 300-350 million chronic carriers worldwide. About 75% of all cases occur in Asia. An estimated 40 million carriers are in India

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The Hepatitis B Virus Core: HBcAg Lipid Bilayer HBsAg Protein Viral DNA DNA POL

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Complications of Chronic HBV Infection Cirrhosis Decompensated liver disease Hepatocellular carcinoma Death

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Treatment approaches for chronic HBV infection Antiviral chemotherapy, especially nucleoside analogues. Manipulating the immune response (immunomodulatory agents, vaccines). Gene therapy.

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Limitations of interferon - ? Rate of HBeAg disappearance in unselected patients ranges from 20% to 30%. Individuals who are immunosuppressed and have high levels of viral replication or low levels of serum aminotransferases are unlikely to respond. Interferon-? is also not effective in vertically acquired infection, and is a particular problem in Asia. Administration of interferon- ? is cumbersome, costly and limited by side effects.

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Mode of Action of Lamivudine HBV replication requires synthesis of an RNA intermediate for reverse transcription. The 5’ triphosphate derivative of lamivudine competitively blocks the reverse transcriptase activity of HBV and acts as a chain terminator. Importantly, lamivudine does not inhibit mitochondrial DNA or marrow progenitor cells, and is therefore well-tolerated.

Slide 8 :

THE ASIA HEPATITIS LAMIVUDINE STUDY 1-year, double-blind trial of lamivudine in 358 Chinese patients with chronic hepatitis B Patients were randomly assigned to receive 25 mg or100 mg of lamivudine, or placebo Primary end point -- reduction of at least 2 points in the Knodell necroinflammatory score Secondary efficacy variables included HBeAg and HBsAg seroconversion, sustained suppression of HBV DNA, and normal ALT values on at least 2 consecutive occasions NEJM 1998;339:61-8

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power9 on Apr 22, 2009 Says :

very good presentations

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	SlidesOnline 1 Years ago. Category: other

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Types of Viral Hepatitis. Hepatitis Aenteric; Hepatitis Bparenteral; Hepatitis Cparenteral; Delta h more Types of Viral Hepatitis. Hepatitis Aenteric; Hepatitis Bparenteral; Hepatitis Cparenteral; Delta hepatitisparenteral; Hepatitis Eenteric ... less

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